Epidemiologic studies have suggested an association between hepatitis C virus (HCV) infection and antigendriven
lymphoproliferative disorders, in particular marginal zone lymphomas. We describe a patient with chronic hepatitis
C, immune thrombocytopenia, and splenic marginal zone lymphoma who, after eradication of HCV with
sofosbuvir and ribavirin, exhibited complete remission of both hematologic conditions.