Volume 5 | January 2018
Image | Small Bowel

Chronic Diarrhea as the Only Symptom in a Patient With Duodenal-Colo-Renal Primary Fistula

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Viviana Parra, MD1, Javier Preciado Aponte, MD1, Margarita Huertas Quintero, MD1, Sara Garcia, MD2,
and Luis Carlos Sabbagh, MD3

1Division of Gastroenterology, Clínica Universitaria Colombia, Fundación Universitaria Sanitas, Bogotá, Colombia
2Division of Radiology, Clínica Reina Sofía, Fundación Universitaria Sanitas, Bogotá, Colombia
3Division of Gastroenterology, Clínica Universitaria Colombia, Clínica Reina Sofía, Bogotá, Colombia

ACG Case Rep J 2018;5:e7. http://dx.doi.org/10.14309/crj.2018.7. Published online: January 17, 2018.

Case Report

A 91-year-old woman presented to our center complaining of nonbloody diarrhea for 6 months and an associated 10-kg weight loss. Her initial lab results suggested hypochromic microcytic anemia. Upper endoscopy showed a fistula between the second portion of duodenum and the right colon (Figure 1). Through the fistula tract, a solid viscera with a nodular mucosa was visible in the lumen of the right colon (Figure 2). Abdominal computed tomography revealed a mass between the right colon, the second portion of duodenum, and the right kidney; this allowed the passage of oral contrast between these structures, confirming that the solid viscera seen on endoscopy was in fact the right kidney (Figure 3). Histology of the biopsied viscera confirmed a poorly differentiated renal carcinoma. Given the stage of her disease, age, and comorbidities, the patient was referred for palliative management; 2 months later, the patient died.

Figure 1. Upper endoscopy showing the duodenocolonic fistulae.

Duodenocolic fistulas are classified into primary and secondary groups; primary fistulas can be due to infectious etiology, Crohn’s disease, peptic ulcer disease, or active malignancies without any prior surgeries.1,2 Secondary fistulas can develop as a complication after a major gastrointestinal surgery. Colorenal and duodenal-renal fistulas, however, are uncommon. These occur primarily in patients who have undergone procedures such as percutaneous nephrolithotomy or cryoablation for renal cell carcinoma; less frequently, they occur with chronic kidney infection or tuberculosis.3

Figure 2. Upper endoscopy suggestive of solid endoluminal viscera in the lumen of the right colon.

The only previously reported case of a secondary duodeno-colo-renal fistula was described in Taiwan, in a patient with renal squamous cell carcinoma in association with nephrolithiasis who underwent nephrolithotomy.3 Ours is the first case of a primary duodeno-colo-renal fistula originating from an advanced renal tumor.

Fistula management is guided by the patient’s disease stage, nutritional status, and comorbidities. In a localized disease, management options range from nephrectomy, right hemicolectomy with a pancreaticoduodenectomy, or segmental duodenectomy. In more advanced cases, an extensive bowel resection or palliative options like tube jejunostomy/loop ileostomy can be offered.1-5 Palliative management was offered for our patient due to her age, comorbidities, and the advanced state of her disease.

Figure 3. (A) Coronal and (B) axial computed tomography of the duodeno-colo-renal fistulae.


Disclosures

Author contributions: V. Parra and JP Aponte wrote the manuscript. MH Quintero, S. Garcia, and LC Sabbagh provided the images. JP Aponte is the article guarantor.

Financial disclosure: None to report.

Informed consent was obtained for this case report.

Correspondence: Viviana Parra, Carrera 21 No. 127-03, Reina Sofia Clinic, Department of Gastroenterology, Bogota, Colombia (viviparravargas@gmail.com).

Received June 25, 2017; Accepted November 8, 2017


References

  1. Kamani F, Hessami R, Abrishami A. Benign duodenocolic fistula as a complication of peptic ulcer disease. Gastroenterol Hepatol Bed Bench. 2015;7(1):72–5. PubMed
  2. Kornfield HJ, Hogan RA. Duodenocolic fistula. Calif Med. 1971;115(5):58–61. PubMed
  3. Chung S-D, Sun H-D, Hung S-F, Chiu B, Chen Y, Wu J-M. Renal stone-associated squamous cell carcinoma and pyelo-colo-duodenal fistula. Urology. 2008;72(5):1013. Article | PubMed
  4. Guraya SY, Murshid KR. Malignant duodenocolic fistula. Various therapeutic surgical modalities. Saudi Med J. 2004;25(8):1111–4. PubMed
  5. Majeed TA, Gaurav A, Shilpa D, Preeti J, Sanjay S, Manisha S, et al. Malignant coloduodenal fistulas-review of literature and case report. Indian J Surg Oncol. 2011;2(3):205–9. Article | PubMed

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© 2018 Parra et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0.