Volume 4 | August 2017
Case Report | Colon

Lower Gastrointestinal Bleeding Secondary to Intestinal Histoplasmosis in a Renal Transplant Patient

Download PDF

Taseen A. Syed, MD1, George Salem, MD2, and Donald J. Kastens, MD2

1Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
2Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma, OK

ACG Case Rep J 2017;4:e93. http://dx.doi.org/10.14309/crj.2017.93. Published online: August 2, 2017.


Histoplasmosis is the most common endemic mycosis in the United States. Symptomatic gastrointestinal histoplasmosis is a rare entity. We report a case of isolated intestinal histoplasmosis that manifested as severe lower gastrointestinal bleeding in a renal transplant patient. The patient developed hematochezia, and colonoscopy showed diffuse, extensive areas of cratered, ulcerated mucosa in the entire colon. Biopsy showed prominent mucosal and submucosal infiltrate of plump histiocytes containing intracytoplasmic yeast forms morphologically compatible with florid histoplasmosis.


Histoplasma capsulatum is a soil-dwelling, saprophytic, dimorphic fungus that causes fungal disease after inhaling particles from the ground contaminated with a bird’s droppings in well-recognized endemic areas.1 While disseminated histoplasmosis is a well-known disease entity, gastrointestinal (GI) histoplasmosis is an uncommon disease with variable manifestations. This disease has a tendency to occur in immunocompromised populations, with a significant prevalence noted in the AIDS population.2,3 The disease entity can have catastrophic consequences if there is a delay in the diagnosis and treatment. Appropriate treatment with an antifungal regimen can lead to rapid recovery.

Case Report

A 69-year-old man with a history of coronary artery disease, congestive heart failure, and end stage renal disease after kidney transplant from a cadaveric donor was admitted initially for urosepsis secondary to pyelonephritis. The transplant had a cytomegalovirus (CMV)-negative recipient/positive donor profile. He was on tacrolimus, mycophenolate, and prednisone. He was treated with antibiotics and showed clinical improvement. During his hospital stay, the patient developed hematochezia over the course of 24 hours. On examination, he reported having spikes of fever over the previous 48 hours prior to the GI bleeding. A digital rectal examination revealed maroon-colored blood in the rectal vault, while the rest of the physical examination was within normal limits. Labs showed a significant drop in hemoglobin from 7.9 to 6.6 g/dL, with an inadequate response to 2 units of blood transfusion. Additionally, the patient tested negative for Clostridium difficile infection. A colonoscopy after appropriate resuscitation showed maroon-colored clotted blood in the rectum along with diffuse, extensive areas of cratered, ulcerated mucosa in the cecum and the ascending, transverse, descending, and sigmoid colon areas (Figure 1). Biopsies revealed prominent mucosal and submucosal infiltrate of the plump histiocytes containing intracytoplasmic yeast forms, morphologically compatible with the histoplasma species seen on the periodic acid schiff stain (Figure 2).

Figure 1. Colonoscopy revealing (A) maroon-colored clotted blood in the rectum, (B) cratered, ulcerated mucosa in the cecum, (C) an ulcer in sigmoid colon, and (D) an ulcer in splenic flexure.

The findings were consistent with colonic histoplasmosis. CMV/herpes simplex virus stains were negative on the biopsy sample. A silver stain showed innumerable intracytoplasmic yeasts, morphologically compatible with the histoplasma species, as well as a few larger yeast forms with thickened walls and pseudohyphae. The histoplasma urine antigen was positive. The patient was started on an intravenous itraconazole treatment for intestinal histoplasmosis. He showed symptomatic improvement after 3 days of the treatment, including resolution of the hematochezia and improvement in his hemodynamic status.

Figure 2. Biopsy showing plump histiocytes containing intracytoplasmic yeast forms.


Histoplasmosis is a systemic disease that affects the bone marrow, lungs, liver, and spleen, mostly by involving the reticuloendothelial system, with hematogenous spread being the primary mechanism of dissemination.4 Geographically, histoplasma capsulatum is mostly concentrated in the Ohio, Missouri, and Mississippi river valleys.5,6 Immunocompetent individuals have clinically silent infections and recover without any medical intervention. Immunosuppression is the number one cause of histoplasmosis manifesting as a syndrome, and most cases are reported in the AIDS-affected population.2,5 Transplant recipients are the second population with an increased incidence of reported histoplasmosis.7 The disease’s clinical presentation is variable. Pulmonary involvement as acute or chronic pulmonary disease in the form of pneumonia, pulmonary nodules, cavitary lung disease, and broncholithiasis is the most common presentation. The disseminated disease can present with rheumatological, dermatological, and GI involvement. GI involvement commonly reveals itself as GI bleeding, intestinal obstruction, or perforation.8 Hepatosplenomegaly with lymphadenopathy can be seen upon physical examination. In imaging, it may mimic malignancy findings such as an apple core appearance, napkin-ring constrictions, or circumferential thickening of the bowel.5

Intestinal histoplasmosis most commonly involves the large intestine as compared to small intestine, especially the ileocecal region.4,9-12 Colonic histoplasmosis has a tendency to mimic other diseases, primarily inflammatory bowel disease, colonic adenocarcinoma, or lymphoma. This can lead to the administration of inappropriate therapies or unnecessary surgical interventions. It is important to consider intestinal histoplasmosis in the differential diagnosis for diarrhea, fever, GI bleeding, bowel mass, obstruction, or perforation, particularly in immunosuppressed populations.4,5 GI involvement is secondary to a hematogenous spread to the lymphatic tissue of the intestine. Isolated GI histoplasmosis is a rare clinical presentation with few cases reported in the literature.13 The most common isolated GI presentation is diarrhea, fever, and abdominal pain.14-16

Several cases of GI histoplasmosis have been reported.15,17,18 Though rare, cases of intestinal histoplasmosis presenting as lower GI bleeding have been reported in AIDS patients. There are only 3 documented cases of intestinal histoplasmosis in the renal transplant population, and all of these patients presented with intestinal perforation.7,19 Our case of isolated intestinal histoplasmosis presenting as lower GI bleeding in a renal transplant patient is the first of its type. This clinical presentation should alert gastroenterologists to this possible diagnosis in renal transplant patients.


Author contributions: TA Syed and G. Salem wrote the mansucript and performed the literature review. DJ Kastens edited the manuscript and is the article guarantor.

Financial disclosure: None to report.

Informed consent was obtained for this case report.

Correspondence: Taseen A. Syed, Department of Internal Medicine, University of Oklahoma Health Sciences Center, PO Box 26901, WP1140, Oklahoma City, OK 73104 (taseen-syed@ouhsc.edu).

Received March 29, 2017; Accepted June 12, 2017


  1. Bates R, Wan SH, Sohail MR. 44-Year-old man with abdominal pain, fever, and bloody diarrhea. Mayo Clinic Proceedings. 2015;90(6):e59–e62. Article | PubMed
  2. Romano RC, Soape MM, Thirumala S, Ghandour E. Disseminated histoplasmosis mimicking metastatic disease of the colon and omentum: Report of a case and literature review. Arab J Gastroenterol. 2015;16(2):66–8. Article | PubMed
  3. Trombetta L, Schtirbu R, Bava AJ. [Intestinal histoplasmosis in an HIV positive patient]. Medicina (B Aires). 2007;67(5):521–2. PubMed
  4. Patel NM, Schwartz DJ. Lower GI bleeding from ileocolonic histoplasmosis. Gastrointest Endosc. 2011;74(6):1404–5. Article | PubMed
  5. Garcia RA, Jagirdar J. Colonic histoplasmosis in acquired immunodeficiency syndrome mimicking carcinoma. Ann Diagn Pathol. 2003;7(1):14–19. Article | PubMed
  6. Mandell W, Goldberg DM, Neu HC. Histoplasmosis in patients with the acquired immune deficiency syndrome. Am J Med. 1986;81(6):974–8. Article | PubMed
  7. Zainudin BM, Kassim F, Annuar NM, Lim CS, Ghazali AK, Murad Z. Disseminated histoplasmosis presenting with ileal perforation in a renal transplant recipient. J Trop Med Hyg. 1992;95(4):276–9. PubMed
  8. Heneghan SJ, Li J, Petrossian E, Bizer LS. Intestinal perforation from gastrointestinal histoplasmosis in acquired immunodeficiency syndrome: Case report and review of the literature. Arch Surg. 1993;128(4):464–6. Article | PubMed
  9. Nudelman HL, Rakatansky H. Gastric histoplasmosis. A case report. JAMA. 1966;195(1):44–6. Article | PubMed
  10. Soto Tarazona AR, Meza Flores JL, Garrido Rivadeneyra D, Cok Garcia J. [Gastric histoplasmosis simulating a malignant gastric ulcer]. Rev Gastroenterol Peru. 2003;23(3):221–4.PubMed
  11. Hindupur S, Despotovic V. Gastric histoplasmosis. Lancet Infect Dis. 2006;6(1):60. Article | PubMed
  12. Becherer PR, Sokol-Anderson M, Joist JH, Milligan T. Gastrointestinal histoplasmosis presenting as hematochezia in human immunodeficiency virus-infected hemophilic patients. Am J Hematol. 1994;47(3):229–31. Article | PubMed
  13. Barros RA, Monteverde MJ, dElizalde S, Barros AS, Barros RF. [Gastrointestinal histoplasmosis: An atypical presentation]. Acta Gastroenterol Latinoam. 2013;43(1):31–5. PubMed
  14. Brett MT, Kwan JT, Bending MR. Caecal perforation in a renal transplant patient with disseminated histoplasmosis. J Clin Pathol. 1988;41(9):992–5. Article | PubMed
  15. Suh KN, Anekthananon T, Mariuz PR. Gastrointestinal histoplasmosis in patients with AIDS: Case report and review. Clin Infect Dis. 2001;32(3):483–91. Article | PubMed
  16. Kahi CJ, Wheat LJ, Allen SD, Sarosi GA. Gastrointestinal histoplasmosis. Am J Gastroenterol. 2005;100(1):220–1. Article | PubMed
  17. Cappell MS, Mandell W, Grimes MM, Neu HC. Gastrointestinal histoplasmosis. Dig Dis Sci. 1988;33(3):353–60. PubMed
  18. Lamps LW, Molina CP, West AB, Haggitt RC, Scott MA. The pathologic spectrum of gastrointestinal and hepatic histoplasmosis. Am J Clin Pathol. 2000;113(1):64–72. Article | PubMed
  19. Kourda N, Mlika M, Zidi YS, Zermani R, Ben Jilani S. [Cecal perforation in a kidney transplant patient: Disseminated histoplasmosis.]Med Trop (Mars). 2010;70(5-6):533—6. PubMed

CC Icon

© 2017 Syed et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0.