Volume 5 | January 2018
Image | Pancreas/Biliary

Pearl-White Gallstones Causing Choledocholithiasis

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Patrick Stoner, DO1, Alexander Schlachterman, MD2, Eric Hilgenfeldt, MD1, and Peter Draganov, MD2

1Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL
2Department of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine,
Gainesville, FL

ACG Case Rep J 2018;5:e4. http://dx.doi.org/10.14309/crj.2018.4. Published online: January 17, 2018.

Case Report

A 71-year-old woman who had previously undergone cholecystectomy several years prior presented with nausea, vomiting, and right upper quadrant abdominal pain. Computed tomography of her abdomen revealed a dilated common bile duct measuring 11 mm in diameter. She underwent endoscopic retrograde cholangiopancreatography (ERCP) for evaluation. A sphincterotomy with balloon extraction revealed several white stones as the cause of her choledocholithiasis (Figure 1). Her symptoms resolved, and she fully recovered to her previous state of health.

Figure 1. (A) A large stone adjacent to the ampulla after balloon extraction at ERCP. (B) Three pearl-white stones in the duodenum. (C) Triangular pearl-white stone on gauze after ERCP.

Gallstones have traditionally been divided into 3 main categories based on cholesterol content: cholesterol stones (cholesterol content >70%), mixed stones (cholesterol content 30–70%), and pigment stones (i.e., black or brown stones, cholesterol content <30%).1-3 Cholesterol stones consist of cholesterol monohydrate and can also include a mixture of calcium salts, bile acids, pigments, and glycoprotein (with the major components being cholesterol and protein constituents).2,4 Mixed stones are composed of varying amounts of cholesterol and the above components. Cholesterol stones usually range in color from pale yellow to yellow-green or brownish yellow, and they are round or oval with smooth surfaces.2 The stones in our case were presumed to be cholesterol stones given their light color and characteristic shape and appearance; however, their composition was never analyzed in the laboratory. Our literature review of studied gallstones did not reveal any combination of chemical components known to cause a pearl-white color as seen in our case. Thus, we report this case as a rare finding on ERCP.


Disclosures

Author contributions: P. Stoner performed the literature review and wrote the manuscript. A. Schlachterman provided the images, performed the literature review, and edited the manuscript. E. Hilgenfeldt edited the manuscript. P. Draganov edited the manuscript and is the article guarantor.

Financial disclosure: None to report

Informed consent was obtained for this case report.

This publication is the only valid version of this article.

Correspondence: Patrick Stoner, Department of Internal Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL (patrick.stoner@medicine.ufl.edu).

Received August 5, 2017; Accepted September 26, 2017


References

  1. Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, biliary tract and pancreas (e-book), 3rd ed. Amsterdam: Elsevier; 2014;996–9.
  2. Qiao T, Ma RH, Luo XB, Yang LQ, Luo ZL, Zheng PM. The systematic classification of gallbladder stones. PLoS One. 2013;8(10):e74887. Article | PubMed
  3. Hamamci M, Karaahmet F, Ekiz F, Yuksel O, Başar O, Coban S. Like a pearl: A rare, white, common bile duct stone in an elderly adult. J Am Geriatr Soc. 2014;62(9):1816. Article | PubMed
  4. Reshetnyak VI. Concept of the pathogenesis and treatment of cholelithiasis. World J Hepatol. 2012;4(2):18–34. Article | PubMed

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© 2018 Stoner et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0.