Volume 5 | December 2018
Case Report | Colon

Fusobacterium Septicemia with Liver and Lung Abscesses Due to Diverticulitis

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Akshay Sharma, MD1, Sachin Goyal, MD2, Camelia Arsene, MD, PhD, MHS1, Geetha Geetha Krishnamoorthy, MD1, and Murray Ehrinpreis, MD2

1Department of Internal Medicine, Sinai Grace Hospital, Detroit Medical Center/Wayne State University, Detroit, MI
2Department of Internal Medicine, Division of Gastroenterology, Detroit Medical Center/Wayne State University, Detroit, MI

ACG Case Rep J 2018;5(1):e99. http://dx.doi.org/10.14309/crj.2018.99. Published online: December 19, 2018.


The Fusobacterium species is known for its association with septic thrombophlebitis of the internal jugular vein (Lemierre’s syndrome). Lemierre’s syndrome is associated with septic emboli to the liver and lungs, often causing multiple abscesses. We present a unique case of Fusobacterium septicemia in which the bacteria invaded the portal vein through the gastrointestinal mucosa due to diverticulitis and spread hematogenously to the liver and lungs, causing abscesses. It was treated successfully with 6 weeks of antibiotics. Physicians should be aware of this rare pathogen and suspect its presence in severe pharyngitis or culture-negative liver abscess.


Fusobacterium species is an obligate anaerobe residing in the oropharyngeal and gastrointestinal (GI) mucosa. Until recently, it was thought to be a rare cause of serious infections in humans.1 It is known to cause Lemierre’s syndrome, which is characterized by an oropharyngeal infection followed by septic thrombophlebitis of the internal jugular vein with embolization to different organs, including lungs and liver.2 Although Fusobacterium infection originating in the GI tract is rare and seldom reported, it can invade the GI mucosa and cause bacteremia with fatal complications.3-5

Case Report

A 52-year-old man with a past medical history of hypertension and hidradenitis suppurativa presented with productive cough, chills, diarrhea, and decreased appetite for 1 week. Physical exam was significant for blood pressure 99/58 mm Hg, heart rate 100 beats/min, respiratory rate 20 breaths/min, and temperature 39.1°C. His head, neck, and throat examination was completely benign, with no lymphadenopathy, neck swelling/tenderness, tonsillar enlargement, or exudates. Abdominal examination revealed mild tenderness in the right upper quadrant without any peritoneal signs. Murphy’s sign was negative. He had normal bowel sounds in all quadrants. Auscultation of the lungs revealed coarse crackles over the right lung base that did not disappear with deep breaths. Skin examination revealed purulent drainage from 2 tender, fluctuant masses 2–3 cm in diameter in the left and right axillary regions. His laboratory tests revealed neutrophilic leukocytosis 17.2 × 109/L with 12% bands. Lactic acid level was 3.5 mg/dL. Chest radiograph was normal.

Figure 1. Contrast-enhanced abdominal computed tomography (CT) showing multiple liver abscesses.

Blood cultures were obtained, and the patient was started on intravenous ceftriaxone, doxycycline, and metronidazole to address the possible right lower lobe pneumonia as well as the axillary abscesses. Incision and drainage of the abscesses was performed, but anaerobic culture and Gram stain were negative. Streptococcal pneumonia antigen, legionella urine antigen, mycoplasma antibody IgM, polymerase chain reaction for influenza A, B, and RSV, and DNA amplification for Clostridium difficile came back negative. Blood cultures were positive for Fusobacterium species on day 5 of admission. The patient was switched to ceftriaxone and clindamycin, but he continued to have persistent fever and tachycardia. Due to the persistent mild right upper quadrant abdominal pain, he underwent abdominal ultrasound, which showed a liver with heterogeneous texture suspicious for abscesses. Abdominal computed tomography (CT) demonstrated diverticulitis involving the distal descending and proximal sigmoid colon along with multiple liver abscesses and a lung abscess (Figure 1). A CT-guided liver fine-needle aspiration core biopsy showed portal triaditis and findings consistent with liver abscess with a negative culture (Figure 2). It showed no signs of malignancy. The patient was switched to ampicillin-sulbactam, which was continued for 6 weeks as he showed clinical improvement. Repeat CT of abdomen in 3 weeks showed that the abscesses were nearly resolved (Figure 3). The patient underwent a follow-up colonoscopy, which was negative for polyps or malignancy.

Figure 2. Hematoxylin and eosin stain of a cell block section of a liver abscess showing benign hepatocytes, associated numerous neutrophils, and degenerated hepatocytes (200×).

Figure 3. Contrast-enhanced abdominal CT after 3 weeks of treatment with ampicillin-sulbactam showing resolution of liver abscesses.


Fusobacteria are anaerobic, nonsporulating, Gram-negative bacilli that exhibit pleomorphism as well as irregular staining.F. nucleatum is the most common source of infection, while F. necrophorum is the most virulent species.7 In one study, the incidence of such infections was estimated to be as low as 5.5 cases per million population per annum.8 It has, however, recently been found to cause pharyngitis more commonly than streptococcus in young adults.9 Its prevalence had declined considerably since the advent of antibiotics, but it has been on the rise again for the past 20 years.10One of the proposed explanations for this is the conservative use of antibiotics in the last 2 decades, during which time multiple cases of Lemierre’s syndrome have been reported. This disease has several complications, such as osteomyelitis, meningitis, and acute respiratory distress syndrome.11 Mortality was extremely high (90–100%) in the preantibiotic era but has diminished with the advent of antibiotics.11

Even though Fusobacterium most commonly causes bacteremia through the oropharynx and internal jugular vein, recent literature has shown that it can readily invade the GI mucosa as well and cause suppurative thrombophlebitis of the portal vein (pylephlebitis) in the setting of an inflammatory process in the gut.3 Our case adds to this evidence and demonstrates how it can also cause septic emboli in the liver and lungs through the portal vein, similar to conventional Lemierre’s syndrome, in which the site of infection is typically the oropharynx and involves the internal jugular vein. Antibiotics have improved survival from Fusobacterium infection. However, mortality is still quite high (10–15%), as presented in other recent case reports.3

Another case of Fusobacterium septicemia and liver abscess was recently reported in which the source was found to be colorectal cancer.4 Recent literature has also shown an increased risk of colorectal cancer in patients with bacteremia from Fusobacterium nucleatum.12 Fusobacterium infection is difficult to diagnose because it is a fastidious organism that is difficult to culture and lacks pathognomonic symptoms. Fusobacterium may be resistant to penicillin, and there is widespread resistance to erythromycin and other macrolides.11 It is treated with ampicillin-sulbactam, piperacillin tazobactam, metronidazole, or clindamycin.11

Fusobacterium can invade the GI mucosa due to an underlying pathology and cause sepsis with potentially fatal complications like liver and lung abscess. However, it can be successfully treated with early recognition and appropriate antibiotic treatment as illustrated by our case. Fusobacterium is a rare cause of liver abscess, and infection can occur by hematogenous seeding not only from the internal jugular vein secondary to tonsillar abscess, but also through the portal vein secondary to an underlying pathology of the gut. It is difficult to culture and therefore should be considered as an etiology in culture-negative liver abscess. Fusobacterium infection should be suspected in patients with severe exudative pharyngitis and culture-negative abscesses of the liver or lung. In cases of Fusobacterium septicemia in which the source of infection is unclear, a thorough investigation for an intra-abdominal pathology should be done, including a colonoscopy to rule out colorectal cancer as the cause of bacteremia.


Author contributions: All authors contributed equally to the writing and editing of the manuscript. G. Krishnamoorthy is the article guarantor.

Financial disclosure: None.

Informed consent was obtained for this case report.

Correspondence: Akshay Sharma, MD, 4201 Antoine St, Ste 2E, Detroit, MI 48201 (g.akshaysharma@gmail.com).

Received March 8, 2018; Accepted October 29, 2018


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